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KMID : 0980720090280020279
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Keimyung Medical Journal
2009 Volume.28 No. 2 p.279 ~ p.285
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Clinical efficiency of HPV DNA test as a screening test of cervical cancer
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Kim Ji-Hae
Ryoo Nam-Hee
Ha Jung-Sook
Jeon Dong-Suk
Kim Jae-Ryong
Cho Chi-Heum
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Abstract
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In spite of the enforcement of the screening program by cervical cytology (Pap smear), false negativity of conventional cytology is problematic and the sensitivity of cytology is highly variable. Therefore, newly developed tests based on molecular method to detect Human Paillomavirus (HPV) DNA have been introduced. Authors evaluated the sensitivity and specificity with efficacy of HPV DNA test as a screening test for cervical cancer according to the biopsy which is a gold standard method. Thirty-three of 52 (63.4%) patients who showed higher grade of severity than CIN II in biopsy were all positive (100%) in HPV DNA test, but Pap smear showed negative in one patient. Among 62 patients with positive HPV DNA but without results of cervical biopsy, 7 patients later revealed advancement of cytological findings during the first year
of follow-up. Since HPV DNA test showed higher sensitivity and negative predictive value for the detection of high-grade cervical lesions than cytology, it would be clinically efficiently used as a primary screening test for cervical cancer. In addition, more effective guidelines for combined usage with cytology would need to be established and further studies would also be required.
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KEYWORD
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cervical cancer, HPV, hybrid capture, Pap smear
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